4′-Amino-2,2′′-dioxo-2,2′′,3,3′′-tetrahydro-1H-indole-3-spiro-1′-cyclopent-3′-ene-2′-spiro-3′′-1H-indole-3′,5′,5′-tricarbonitrile dihydrate
نویسندگان
چکیده
In the title compound, C(22)H(12)N(6)O(2)·2H(2)O, the cyclo-pentene ring adopts an envelope conformation, with the spiro C atom bonded to the dicyano-substituted C atom deviating by 0.437 (2) Å from the plane of the remaining four atoms in the ring. The puckering and smallest displacement asymmetry parameters for the ring are q(2) = 0.275 (2) Å, ϕ = 212.4 (4)° and Δ(s)(C(2)) = 2.7 (2). The dihedral angle between the two indole groups is 60.1 (1)°. The structure contains inter-molecular N-H⋯O hydrogen bonds involving the indole groups and O-H⋯O and O-H⋯N hydrogen bonds involving the water mol-ecules.
منابع مشابه
A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates
The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the compounds was determined by (1)H and (13)C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested co...
متن کاملrac-Methyl (1R,3′S)-1′,1′′-dimethyl-2,2′′-dioxo-2H-dispiro[acenaphthylene-1,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxylate
In the title compound, C(26)H(22)N(2)O(4), the pyrrolidine ring adopts a twisted conformation and the other five-membered rings adopt envelope conformations with the spiro C atoms as the flap atoms. The naphthalene ring system of the dihydro-acenaphthyl-ene group forms dihedral angles of 89.2 (9) and 75.5 (6)° with the pyrrolidine and indole rings, respectively. The pyrrolidine ring makes a dih...
متن کاملEthyl 2-amino-7,7-dimethyl-2′,5-dioxospiro[5,6,7,8-tetrahydro-4H-chromene-4,3′(2′H)-1H-indole]-3-carboxylate
In the mol-ecule of the title compound, C(21)H(22)N(2)O(5), the indole system and the spiro-pyran ring are almost planar [maximum deviations of 0.0447 (17) and 0.0781 (17) Å, respectively]; the dihedral angle between them is 84.6 (3)°. The remaining six-membered ring adopts a twisted conformation. Intra-molecular N-H⋯O hydrogen bonds occur. In the crystal structure, intera-molecular N-H⋯O and C...
متن کامل3-(4-Fluorophenyl)-1-[1′-(4-fluorophenyl)-2-oxo-5′,6′,7′,7a′-tetrahydro-1H-indole-3(2H)-spiro-3′(2′H)-1H′-pyrrolizin-2′-yl]prop-2-en-1-one
In the title compound, C(29)H(24)F(2)N(2)O(2), one of the pyrrolidine rings of the pyrrolizine system is disordered over two sites, with occupancy factors 0.734:0.266 (12). Both components of the disordered pyrrolidine ring adopt envelope conformations, whereas the other pyrrolidine ring adopts a twist conformation. The mol-ecules are linked into centrosymmetric dimers by N-H⋯O hydrogen bonds a...
متن کامل2-Amino-4′-bromo-2′,5-dioxo-4H,5H-pyrano[3,2-c]chromene-4-spiro-3′(2′H)-1′H-indole-3-carbonitrile N,N-dimethylformamide solvate
In the mol-ecule of the title compound, C(20)H(10)BrN(3)O(4)·C(3)H(7)NO, the spiro pyran ring adopts a twist conformation. The indole and coumarin ring systems are each nearly planar, and are oriented at a dihedral angle of 79.29 (3)°. In the crystal structure, inter-molecular N-H⋯O, N-H⋯N, C-H⋯O and C-H⋯N hydrogen bonds link the mol-ecules.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 64 شماره
صفحات -
تاریخ انتشار 2008